ABSTRACT
Objective To understand the current status of medication compliance in the patients with postherpetic neuralgia (PHN)and its influencing factors.Methods The cross-sectional survey method was adopted to investigate the status quo of medi-cation compliance among PHN patients in the pain clinic of the Southwest Hospital of Army Military Medical University from Janu-ary of 2014 to March of 2015.Then the influence factors of medication compliance were analyzed by using the using the Logistic re-gression method.Results A total of 396 PHN patients were included 52.3% of patients had good medication compliance,while 47.7% had poor compliance.The univariate analysis showed that the age,educational level,marital status,living condition,economic status,degree of pain,disease course,medical insurance reimbursement,adverse drug reactions and complicating other diseases were the factors affecting the medication compliance(P<0.05).The multivariate Logistic regression analysis results showed that the age,educational level,marital status,living condition,economic status,degree of pain,disease course,medical insurance reimburse-ment,adverse drug reactions and complicating other diseases were the factors affecting the medication compliance.Conclusion The medication compliance in the patients with PHN is not high,there are many factors affecting the medication compliance.It is recom-mended to carry out the health education,strengthen the psychological intervention of the patients and establish the follow-up medi-cation compliance system for improving the medication compliance.
ABSTRACT
Objective To examine the changes of Aβ expression and its related metabolic enzymes in the brains of AD and T2DM mice, so as to explore the possible mechanism of type 2 diabetes mellitus combined with AD.Methods Five-month-old APP/PS1 double transgenic mice, ob/ob mice and the wild-type control mice were employed in this study.Immunohistochemical (IHC) staining, Elisa and Western blot were used to detect SP, Aβ and its related metabolic enzymes.Results A certain number of SPs were observed in the cerebral cortex and hip-pocampus of APP/PS1 mice;SPs were occasionally observed in the cortex of ob/ob mice, while no SP appeared in wild-type mice.Aβ40 and Aβ42 levels were significantly increased in APP/PS1 and ob/ob mice brains as compared with controls (P<0.05), thought both Aβ40 and Aβ42 levels in AD mice were significantly higher than those of ob/ob mice (P<0.05).APP expression level was highest in APP/PS1 mice among 3 groups, and its expressed higher in ob/ob mice than that of control mice (P<0.05).BACE1 expression was notably increased in APP/PS1 and ob/ob mice as compared with control(P<0.05), however, it expressed higher in APP/PS1 mice than ob/ob mice (P<0.05).The expression of Aβ degradation enzyme IDE was reduced in APP/PS1 and ob/ob mice(P<0.05), while lowest in ob/ob mice.Conclusions Overexpression of Aβ may be one of main reasons for T2DM combined AD.